Increased free radical production at various doses of DEP would result in impairment of the defense system leading to an enhanced dose-dependent reproductive toxic effect.
So far, frequently, the only available response to emerging resistance has been the increase in 'firepower', i.e., enhanced doses of the therapeutics.
The discrepancy remains unexplained, but still suggests that the need for enhanced dose intensity of oxaliplatin above 85 mg m−2 requires exploration.
To achieve a PMI of 1% the fitted lines show an enhanced vincristine dose requirement over normal mucosa of 6 times in colonic tumours, and 8 times in small intestinal tumours.
Significant effects of chemical exposure during prenatal development occur for many reasons: a critical window of susceptibility, an enhanced delivered dose to the fetus due to differences in fetal-maternal detoxification/metabolism, formation of unique metabolites, or selective uptake by compartments unique to the fetus including amniotic fluid or placenta.
Such materials can provide several advantages such as a high-packing density, which can lead to enhanced dosing, an increased flexibility of design as these materials naturally interact biologically and a lack of void volume as whole particles can be designed to be active.
Given the prevalence of ARIAs in the bapinezumab trial and their clear association with escalating dose, an enhanced understanding of ARIAs is needed.
This mechanism is a likely explanation why low-dose ciprofloxacin treatment of S. aureus resulted in an enhanced release of LTA and, consequently, to activation of PMN.
In this study, conducted under experimental conditions, a single dose of LIXI enhanced first-phase insulin secretion by 2.8-fold and second-phase insulin secretion by 1.6-fold in response to an iv glucose challenge in people with T2DM.
These results indicate that mice lacking both Slo2.1 and Slo2.2 channels exhibit an enhanced aversion to moderate doses of capsaicin and that Slo2 dKO can influence the acute response to sensory stimuli.
