Increased free radical production at various doses of DEP would result in impairment of the defense system leading to an enhanced dose-dependent reproductive toxic effect.
To achieve a PMI of 1% the fitted lines show an enhanced vincristine dose requirement over normal mucosa of 6 times in colonic tumours, and 8 times in small intestinal tumours.
Significant effects of chemical exposure during prenatal development occur for many reasons: a critical window of susceptibility, an enhanced delivered dose to the fetus due to differences in fetal-maternal detoxification/metabolism, formation of unique metabolites, or selective uptake by compartments unique to the fetus including amniotic fluid or placenta.
This hypothesis was corroborated by the in vivo findings with A2MG MV, where administration of these vesicles led to an enhanced and dose dependent increase in early neutrophil recruitment (i.e. at the 6 h interval) to the peritoneum following CLP (Fig 7F).
The discrepancy remains unexplained, but still suggests that the need for enhanced dose intensity of oxaliplatin above 85 mg m−2 requires exploration.
Such materials can provide several advantages such as a high-packing density, which can lead to enhanced dosing, an increased flexibility of design as these materials naturally interact biologically and a lack of void volume as whole particles can be designed to be active.
So far, frequently, the only available response to emerging resistance has been the increase in 'firepower', i.e., enhanced doses of the therapeutics.
In our study, we did not observe any effect of malnutrition on 2 hour concentrations, Cmax, Tmax, and AUC0 4 of isoniazid, rifampicin, pyrazinamide or ethambutol, even with enhanced dosing.
To determine whether pediatric patients with obesity receiving weight-based dosages of unfractionated heparin (UFH) exhibit an enhanced response when dosed by actual body weight compared with nonobese patients as assessed primarily by the frequency of supratherapeutic anticoagulation.
In order to account for degradation of the prescribed dose gradient at the edge of moving target volumes during delivery, patient-specific margins that consist of edge-enhanced dose intensity maps can be constructed[85].
