Rieben et al. [ 9] showed that IgM enrichment of ivIg preparations leads to an enhanced complement-inhibitory capacity both in vitro and in vivo as compared with pure ivIgG.
It has been suggested that under conditions of enhanced complement activation, a lower local concentration of FH at the cell surface may lead to cell damage.
MBL appears to have a dual mode of action: increased MBL leads to enhanced complement activation and tissue damage, while its deficiency has been linked with defective clearance of apoptotic cells that provide a stimulus for autoantibody formation [ 17].
The present data show that HcpA-bound CFH retains its regulatory capacity and controls both C3b deposition and C3-convertase activity, resulting in enhanced complement regulatory activity.
These findings show that the augmented neutrophil response in Cd59a /– mice was due to enhanced complement activation.
Oxidative stress induces a change on the cellular surface [ 29], which results in binding of MBL leading to enhanced complement mediated injury.
We reasoned that defects in complement regulation would also influence the clinical course of influenza infection by permitting enhanced complement activation.
These mutations result in a "super-B," which forms a hyperactive C3 convertase that is resistant to decay by complement regulators (Table 2; Fig 2B), with enhanced complement activation at endothelial cell surfaces.
Increased properdin in SARs may therefore reflect ongoing in vivo activation of inflammatory and endothelial cells, leading to enhanced complement activation through stabilization of alternative C3 convertases.
Further, we demonstrate that STAT3 is sufficient when constitutively active for triggering the onset of auto-immune myocarditis, involving enhanced complement C3 production and IL-6 signalling amplification in the liver.
Further, we demonstrate that STAT3 is sufficient when constitutively active for triggering the onset of immune-mediated myocarditis, involving enhanced complement C3 production and IL-6 signalling amplification in the liver.
