Sentence examples for an enduring alteration from inspiring English sources

The diagnosis of epilepsy requires two elements: a history of at least one seizure and evidence of an enduring alteration in the brain activity [ 2].

With more chronic exposure, cells adapt by an unknown hypothetical process that results in more permanent modifications to DNA methylation and chromatin structure, leading to enduring alteration of a given epigenetic network.

Kainic acid: enduring alterations in cerebellar morphology and in cerebral catecholamine and GABA concentrations after cerebellar injection in the rat.

As the compound is virtually undetectable in plasma or brain beyond 8 h post-dosing, and since nothing is known about potentially active metabolites, we consider the possibility that single dose treatment with SB-334867 results in enduring alterations to the orexin-1 receptor and/or downstream signalling pathways.

Manipulation of dietary choline levels in pregnant rats has been shown to result in enduring alterations in memory and hippocampal function of the offspring, but the mechanisms underlying these effects remain unclear.

Conclusions: These findings underscore our recent report that CIE during adolescence results in enduring alterations in tonic current and its acute EtOH sensitivity and establish that adolescence is a developmental period during which the hippocampal formation is distinctively vulnerable to long-term alteration by chronic EtOH exposure.

In summary, our findings reveal that low-level GLE produced the most profound and enduring alterations in locomotor activity, another example of nonmonotonic responses.

It has been demonstrated that the enhanced responses to psychostimulants rely on time-dependent neuroadaptations that involves enduring alterations in behavioral and neurochemical responses.

However, the alteration of target glycan expression has been an enduring and major objective of glycobiological experiments concerning lectins.

So began an enduring friendship.

This is an enduring frustration.