The presence of both α-syn and γ-syn in brain deposits in several NDDs may suggest a common element in the mechanism leading to these disorders.
It has been proposed that the binding of N II) ions within the cell nucleus is a crucial element in the mechanism of carcinogenesis.
The finding that antagonism of adenosine-A1 receptors occludes FF and facilitates mossy fiber LTD suggests that this receptor is an intrinsic element in the mechanisms underlying these effects.
If the ions act indirectly through the bilayer or via an intracellular site, however, the E543 residue must still be a crucial element in the coupling mechanism to channel opening.
Thus, this observation demonstrates an important element in underlying the mechanism of PEDF therapy to counteract VEGF-related actions during neoangiogenesis.
Dangerousness, avoidance and character weakness are the main elements in the mechanism underlying stigma against mental illness [ 4].
Conservation of these contacts in AMPA and kainate receptors indicates that they are important determinants of dimer stability and that the dimer interface is a key structural element in the gating mechanism of these glutamate receptor families.
Given the common presence of a local ischemic element in the prolapsing mechanism, this latter observation is anticipated.
Cryptochrome has been suggested as an element of molecular mechanism of the circadian clock in peripheral clocks [13], [14], [25], [26].
The following study identified ENVOY as a central regulatory element in the fine-tuning mechanism of G-protein signaling.
Berilgen et al. [7] were the first to suggest "sinus barotrauma" as a potential mechanism underlying AH, which has been a key element in the subsequent discussion for AH mechanisms [2 5, 9 14, 18 21, 24 27, 32, 35, 39, 40].
