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Both BNP and NT-proBNP are inversely related to the GFR [ 6, 21], and this has been assumed to be an effect of accumulation [ 6, 18].
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More recent evidence also points to an effect of H+ accumulation in the blood on the perception of effort during high-intensity intermittent exercise (Price and Moss 2007), which could also contribute to fatigue indirectly.
Moreover, Del Bigio et al. reported significantly increased GFAP levels in hydrocephalic rats which decreased after shunting suggesting an effect of fluid accumulation and/or raised intracranial pressure on these cells [ 43].
The observed relationship between age of meadows, pollen viability and petal number in those studies suggests a similar effect of accumulation and finally fixation of mutations deleterious to sexual reproduction.
Furthermore, the absence of an effect of rapamycin on the accumulation of protein incorporating radiolabeled leucine may indicate the absence of a rapamycin effect on autophagy.
The failure to observe an effect of HaDREB2 on sHSP accumulation and thermotolerance in seeds could have alternative explanations.
However, we did not detect an effect of mdl-1 on accumulation of the most abundant protein class in C. elegans hermaphrodites, the vitellogenins, which are synthesized in the intestine [ 46].
Likewise, less perirenal fat (p < 0.001) was found in subgroups HDP36 and HDP25 compared to HDH and HDNP, which shows an effect of acupuncture in body weight accumulation (Fig. 6).
The effect of accumulation time was studied in the range of 0 150 s.
The stronger association of tibia lead with PP is consistent with bone lead as a proxy dosimeter for arterial lead accumulation and an effect of chronic lead exposure on vascular structure and function.
These results provide an important clue about the effects of accumulation of ROS on ascorbic acid biosynthesis in P. cornutum.
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