Sentence examples similar to an effect of a mutant from inspiring English sources

So far, only one pathologic effect of a mutant bestrophin-1 has been found.

Most studies have found that only females demonstrated an effect of mutant MC1R.

To better understand the mechanism of the dominant negative activity on the negative regulation of TSHα gene expression, we examined the effects of a mutant TR (Mf-1) from a RTH patient [28], on histone modifications of the TSHα promoter in the absence or presence of T3 using adenovirus-GFP control as well as adenovirus encoding wild-type TRβ or Mf-1 in α-23 cells (Figure 6A).

In a final example, we examined the effects of a mutant kinesin, Kif3B, on LR patterning.

In the mouse model, we describe here, we successfully abolished TWINKLE protein expression, whereas other models and human patients have phenotypes caused by dominant negative effects of a mutant TWINKLE protein expressed against a background of wild-type TWINKLE.

An anti-proliferative effect of a RUNX1 mutant protein may have an oncogenic effect due to an improper balance between proliferation and differentiation.

We characterize a dominant negative effect of a CIII mutant.

Our results demonstrate a potent dominant-negative inhibitory effect of a single mutant p53 allele (p53+/R172H) on UVB-induced lincRNA-p21 transcript levels and UVB-induced apoptosis.

This might be the result of a cytotoxic effect of the mutant.

This may lead to a more potent effect of mutant H3.3 compared to mutant H3.1 in transcriptional dysregulation and contribute to tumorigenesis.

Interestingly, the model predicts a decrease in synaptic connectivity to be an early effect of mutant huntingtin in cortical neurons, supporting the hypothesis of decreased, rather than increased, synchronized cortical firing in HD". to ameliorate cortical microcircuit burst firing.