As a consequence of this slower proliferation, these tumours respond in a similar manner to late-responding normal tissue rather than early responding normal tissue [13 15], thereby removing the rationale for hyperfractionated schedules.
This led us to question whether these early responding transcripts represent a class of genes not processed through the SL mechanism and under transcriptional control.
Hence, typically, late-responding normal tissues have a smaller α/β ratio (about 2 Gy) than either tumour tissue or early responding normal tissues (about 10 Gy) [7].
The most heavily exposed groups included occupants of buildings, passersby, residents of lower Manhattan, and early responding rescue/recovery workers.
Another early responding gene is the putative amidase.
Glioma, early responding target surrounded by late responding tissue: glioblastomas/metastases.
In addition, red marrow and its progenitor cells are known to behave as early responding tissues with limited repair capacity.
These results suggest that the early responding genes are not exceptions to the SL trans-splicing mechanism prevalent in dinoflagellates.
For example, the targets of Traf2 are mainly early responding genes whereas the targets of Ccdc33 have longer temporal responses.
