Most early phase programs use markers of pharmacodynamic response and target engagement/specificity to demonstrate pharmacologic response, including CSF, plasma, and imaging-based biomarkers.
Using this conceptual framework, we found that the Wnt3a-induced transcriptional program is characterized by two distinct phases: an early phase (0 3 hours) and a late phase (3 24 hours).
True, institutional retooling is still in an early phase.
The investigation is still in an early phase.
THE "Artists in the Marketplace" program at the Bronx Museum of the Arts, now in its 17th year, is a kind of total-immersion boot camp for artists in the New York region still in an early phase of their careers.
But the process of identifying victims is still in an early phase, Mr. Forest said.
Colonial America was still in an early phase of its reverence for Shakespeare.
Evaluations using pre- and post-intervention measures or quasi-experimental designs may be appropriate, particularly where a program strategy is implemented in phases and a group that has not yet received the intervention serves as a comparison for a group in an earlier phase of the program.
To address this gap, the US Chinese Anti-Cancer Association (USCACA), with generous support from Jiangsu Hengrui Medicine Co., LTD, has initiated the Early Phase Oncology Research Training EFFORTT) Program [ 15].
If the early phase of the program lives up to the high expectations of its backers, the city government is likely to expand the field of projects it will finance, supporting energy-efficiency initiatives like putting in double-glazed windows or adding insulation.
As TP53 mutations occur in a relatively early stage of colorectal carcinogenesis, the potential deleterious effects of hypoxia on CRC biology may already be programmed in a very early phase of tumour development.
