Instead of merely being a storage depot, adipose tissue is now recognized as an important regulator of energy homeostasis and a central player in the development of insulin resistance [ 1, 2].
TGF-β1 plays an important role in normal wound healing but is also a central player in the development of fibrosis and tissue remodeling.
Obesity is frequently a central player in the development of the metabolic syndrome and should be considered a key component of clinical definitions.
Among the pathways identified as recurrent targets of genetic lesions in DLBCL, NF-κB has emerged as a central player in the development and maintenance of this disease, particularly in the less curable, activated B cell (ABC)- like subtype.
China has been a central player in the development of bitcoin in recent years, but Beijing has spent the last six months cracking down on the cryptocurrency industry — shutting down local exchanges and banning initial coin offerings.
TSLP is a central player in the development of allergic, especially asthmatic symptoms, and has been suggested to represent a missing link in the information flow from antigen-exposed epithelial cells via dendritic cells (DCs) to T helper cells.
TSLP emerged as a central player in the development of allergic symptoms, especially in the airways, and is a prime regulatory cytokine at the interface of virus- or antigen-exposed epithelial cells and dendritic cells (DCs).
GSK3 plays a key role in embryonic development as a central player in the Wnt signaling pathway.
Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy.
A central player in the behind-the-scenes drama over "Moneyball" was Amy Pascal, Sony Pictures' co-chairman and an executive known for taking a strong hand in the development of scripts.
The membrane receptor BRI1 is a central player in the brassinosteroid signaling cascade.
