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We performed cross-validation analyses to assess performance of multivariate Cox models consisting of these markers and standard clinico-pathological covariates, using an average time-dependent Area Under the Receiver Operating Characteristic curves and compared it to nested Cox models obtained by robust backward selection procedures.

The authors propose two pairs of metaheuristic solution approaches, each consisting of a deterministic method (average time-dependent travel speeds for planning) and its corresponding stochastic version (exploiting stochastic information while planning).

Similarly, the stability of each variable was determined as the fraction of reduced models containing the variable; to take performance into account we defined an alternative variable stability score by summing the average time-dependent AUCROCs of the reduced models that include the variable.

The average time-dependent AUCROC measure is a variant of the weighted average of time-dependent ROC curve approaches [ 21- 23].

The average time-dependent AUC is used as an evaluation measure for each genomic profile and the different kinds of networks.

Adjustment for the time was attempted by including a spline term for the time interval since vaccination, but only the average time-dependent change could be modeled, and the result for each child therefore remained somewhat imprecise.

Growth of average time-dependent strain values in RCC beam B2Fe2 and PSC beam PSBFe2 are plotted in Fig. 14 with predicted strain values for P.C beam as per ACI 318 model code.

At 300 days age of concrete the growth of average time-dependent strain in beams B1Fe2 was 21%% less than in beams B1Fe1, due to presence of 0.16 % more area of steel reinforcement.

We, therefore, discuss four assessment methods (average annual electricity mix, average time-dependent electricity mix, marginal electricity mix, and balancing zero emissions) and analyze the corresponding CO2 emissions for Germany in 2030 using an optimizing energy system model (PERSEUS-NET-TS).

The mean average time-dependent AUCROC of the seven-covariate clinico-pathological model is 0.712.

We refer to this measure as the average time-dependent AUCROCs across all death events.

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