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When a germline loss-of-function homozygous mutant was produced by recombining our loxP-flanked Crim1 allele with EIIA-Cre, we found an assemblage of changes (including hemorrhage, edema and syndactyly) very similar to the phenotype of the previously characterized insertional (Pennisi et al., 2007) and germline conditional (Chiu et al., 2012) mutants.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com