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To address this problem, an array of methodologies is used, such as the identification of 'hits' by high-throughput screening (HTS), the development of suitable assays for functional screening in vitro and in cells, and the use of protein structures to aid rational drug design.
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There is now a clear need to discover novel and effective clinical biomarkers using technologies that encompass an array of different methodologies.
Recent advances in molecular biology have created a new array of methodologies for examining the population structure of microbial communities in natural environments.[73] Techniques such as gene probing and polymerase chain reaction (PCR) can provide a very specific and sensitive evaluation of similarities and differences in microbial communities.
Risk assessors, confronted by a wider array of methodologies and data than in the past, should be offered guidance in interpretation because now they have to deal with unaccustomed questions and problems.
These descriptions, coming from a wide array of methodologies, including essays, surveys, qualitative analyses, and observational studies, but from very few empirical data, were grouped into 49 themes, which were clustered into three main categories: physician, teacher, and human characteristics.
Today, it is solidly founded on engineering sciences and an array of systems theoretical methodologies and approaches.
Today, it is solidly founded on engineering sciences and an array of systems-theoretical methodologies and computer-aided tools.
Furthermore, the integration of sequence data with a variety of alternative information is providing valuable and fundamentally new insight into biological processes, as well as an array of new computational methodologies for the analysis of biological data.
We fully expect that the present work will provide the basis for the synthesis of novel barbituric acid derivatives and will result in the development of an array of modern synthetic methodologies to access reductive amide umpolung by electron transfer events.
Unfortunately, the focus on non-random samples and potentially pre-selected flora combined with a very diverse array of methodologies make it impossible to estimate trends in prevalence and incidence from this body of literature.
Such a collection of bewildering array of methodologies and alternatives often poses a difficult challenge to any aspirant who is not a specialist in these techniques.
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