We used S2FST instead of the FST mean estimator from each group of adjacent SNPs, since a measure of FST mean across an array of loci would be more sensitive to those alleles that reached fixation in the form of the opposite allele, and less sensitive for those fixed in the same direction while variance captures this alternation.
Because our objectives included estimating both deep and shallow relationships, we specifically chose an array of loci that were expected to be useful for estimating relationships across the ranges of divergence anticipated.
To further validate the significance of the RNA-seq-derived differential expression analysis, the constitutive expression of an array of housekeeping loci commonly used in qRT-PCR normalization [ 69– 75] was verified in the sequencing datasets after library size normalization.
To further validate the significance of the RNA-seq-derived differential expression analysis, the constitutive expression of an array of housekeeping loci commonly used in qRT-PCR normalization (Ferreira and Cronje 2012; Huggett et al. 2005; Langnaese et al. 2008; Silveira et al. 2009; Wan et al. 2011) was verified in the sequencing datasets after library size normalization.
Based on the intersection of dom with Notch signaling, we expected to identify a broad array of loci, and most of the dom modifiers interact similarly with a strain defective in Notch signaling.
Recently, a separate study using an array of 422 genomic loci detected frequent alterations at 1, 6, 7p, 9, 11q, 12q, 17, 20q and 22q in archival breast cancer specimens [ 23]. cDNA arrays have also detected DNA copy changes of amplicons containing ERRB2 on 17q [ 24- 27].
Genetic markers for differentiation at these scales included partial sequences of mitochondrial cytochrome- c-oxidase subunit I, and an array of nuclear DNA microsatellite loci [ 39].
The information is stored as an array of sequences in the CRISPR locus and can be recalled and used to reconstruct a timeline of events.
The recently discovered microbial immune system CRISPR/Cas contains the CRISPR (clustered regularly interspaced short palindromic repeats) locus, an array of sequence-specific repeats flanking unique spacers, and adjacent cas (CRISPR associated) genes [ 1].
Furthermore, an array of sgRNAs tiling along the target locus enables the visualization of nonrepetitive genomic sequences.
As in figure 2, this prediction is well supported by simulations of a replication fidelity locus with an array of alleles differing in the mutation rate by a constant factor (and acting in an additive fashion to define the genotypic mutation rates), with deleterious mutations assumed to arise in a freely segregating background.
