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In aCGH, differentially fluorescently labeled DNA from test and reference genomes are hybridized to an array of genomic probes derived from the reference genome.
Our extensive foundational knowledge of the biology of D. melanogaster places these flies in a very strong position to contribute to our understanding of outstanding issues and questions in biology, supported by the availability of a sequenced genome (Adams et al., 2000) and an array of genomic resources.
Comparative genomics of the species that make up the M. tuberculosis complex has also added an array of genomic information to our understanding of these organisms.
The E2 ER complex mediates an array of genomic and non-genomic events that orchestrate the expression of a number of genes involved in the regulation of cell proliferation and differentiation.
Microarrays can be used to define gene copy number changes based on cohybridisation of labelled experimental and normal DNA to an array of genomic DNA.
Array-based comparative genomic hybridization (array CGH), i.e. the application of CGH to an array of genomic fragments such as bacterial artificial chromosomes (BACs), has been the method of choice for genome-wide copy-number analysis in the last few years.
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Recently, a separate study using an array of 422 genomic loci detected frequent alterations at 1, 6, 7p, 9, 11q, 12q, 17, 20q and 22q in archival breast cancer specimens [ 23]. cDNA arrays have also detected DNA copy changes of amplicons containing ERRB2 on 17q [ 24- 27].
The circa 70 chloroplast genomes (cpDNAs) of green algae sequenced to date have revealed a remarkable array of genomic architectures, including a wide range of genome sizes, gene repertoires and arrangements, and nucleotide compositions [ 1- 3].
Performing CGH on an ordered array of genomic clones, in place of metaphase chromosomes, dramatically increases the resolution of the technique.
GeneDB (http://www.genedb.org) is a generic database designed to house annotated and curated sequencing data for small genomes, together with a comprehensive array of genomic and proteomic information, collated from publicly available sources.
Taking advantage of the system for comparative studies requires development of a comprehensive array of genomic resources and methods addressing variation at the whole genome scale.
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