We study an access trace containing a sample of Wikipedia's traffic over a 107-day period aiming to identify appropriate replication and distribution strategies in a fully decentralized hosting environment.
While initial RNA-seq took advantage of the accuracy of the technology to avoid replication, recent studies highlight the importance of appropriate replication for a sound RNA-seq data analysis (Liu et al., 2014; Sims et al., 2014; Tarazona et al., 2011).
A major strength of this approach is that, with appropriate replication and controls, it can confirm evolution in response to a specific environmental factor (discussed in more detail later).
If, from one point of view, one might consider that NoSQL databases are more robust due to their replication (i.e. crashes are "faded out" by appropriate replication and consensus algorithms [94]), from another, lack of code maturity and extensive testing might make NoSQL less robust in general [4, 12].
Numerous mechanisms exist to ensure the appropriate replication of chromosomes, including precise control of replication initiation [1], [2].
First, it is unbiased in the sense that it can be applied to any quantitative trait and any genetic polymorphism, much like traditional genetic mapping methods; in fact it can even be applied to previously published data sets, where appropriate replication of phenotype measurements in genetically identical individuals exists.
Indeed, because these variants are rare and often population-specific, it might be difficult to find appropriate replication panels.
With appropriate replication and controls, and following the confirmation of genetic or plastic change and its adaptive significance (as above), exceptionally strong evidence thus would be provided for causal effects.
In the absence of appropriate replication, plasmids may still 'survive' by recombining into the host's chromosome, which is promoted by the presence of suitable sequences for homologous recombination.
