Sentence examples for an apparent defect of from inspiring English sources

Thus, there is an apparent defect of negative selection or regulation of newly generated plasmablasts in SLE, or alternatively, the process is normal but not appropriately terminated.

They lost their normal, symmetrical structure and appeared disorganized, with many aberrant protrusions and an apparent defect in the fusion of membrane extensions.

Unlike previous observations based on MCF-10 A cells, the detached TertHMECs were found to have an apparent defect in the execution of apoptosis and instead, underwent non-apoptotic cell death through simultaneous entosis, cornification, and necrotic processes.

On the surface, a defect in IFN-induced transcription would appear less likely given that ISG43 is an immediate-early ISG [29], [30] and that there is not an apparent defect in classic ISGF3 activation of ISG transcription (e.g., as that of ISG15).

As shown in Figure 7, both the sis1-151 and ydj1∆ mutants showed an apparent defect in the nuclear accumulation of tRNAs under starvation conditions while the zuo1∆ mutant cells were able to accumulate tRNAs in the nucleus.

Notably, comparing with wild-type cells, spt16-m also exhibits an apparent defect in shmoo formation after induction of Sir3p.

This may be because inadequate levels of STAT5 activation result in the readily apparent defect of insufficient milk production whereas increased STAT5 activation produces the less obvious developmental abnormality of precocious alveolar differentiation during pregnancy and, only later, hyperplasia and cancer [ 55, 60, 66, 67].

Although a previous report concluded that disease mutants have a GTPase defect (21), we demonstrate that this apparent defect is largely a reflection of increased GTP dissociation.

Moreover, phenotypic analysis of the DN γδ thymocytes and mature DN γδ T cells from WT, Lck+/− and Fyn+/− mice revealed no appreciable differences in Vγ usage, TCRγδ surface levels and cell surface phenotype (data not shown), indicating that reducing the expression levels of Lck or Fyn resulted in no apparent defect in the development of polyclonal γδ T cells.

Thus the consequences of abolished Edar function on mammary morphology are readily detected in these mutant mice, despite the absence of an apparent functional defect in lactation.

Both single mutants and the double mutant showed no apparent defect at any phase of the Plasmodium life cycle under standard conditions.