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The objectives of the present study were first to identify the MHC and TCR contact residues in the RA-associated epitope using a panel of well-characterized specific T cell hybridomas, second to derive a molecular model to guide APL design, and third, to identify an APL capable of modulating the pro-inflammatory response to the synovial auto-epitope.
An example of such an APL is the alanine substitution at position 4 of the I-Au restricted N-terminal 11-mer peptide of myelin basic protein (MPB) AcN1-11[4A] AcN1-11[4A] a poor immunogen that inhibits the induction of the MPB-specific CD4+ T cell-mediated experimental allergic encephalomyelitis (EAE) model of multiple sclerosis in mice [4].
At mission control, and in an APL auditorium where the rest of the science team was watching, people jumped from their seats and burst into cheers.
We compared patients with APS confirmed by Sapporo criteria (Group 1) with patients with APS-like obstetrical complications with an aPL titer below the intermediate titer (Group 2).
To this end, we retrospectively reviewed the files of all patients referred to our unit (2003 2010) for unexplained pregnancy morbidity, with an aPL test result.
06/03/14 Our work was on the cover of PNAS! 01/22/14 Our paper was selected as an APL Editor's pick in Biophysics! 07/15/13 Sanghoek passed his PhD defense!
Similar(29)
CPFAC is an APL-designed large margin classifier that maximizes the detection of targets for a given false alarm rate.
Baugh was in town for two weeks in June as part of an APL-funded research effort to further assess the usability of the MPL, developed over the past decade as part of the Revolutionizing Prosthetics Program.
Hilliard, who joined APL in 2001, commits up to 12 hours a week to judging public school science, technology, engineering and math competitions and to helping with activities such as MentorNet, Project Lead the Way and Girl Power, an APL-sponsored event that familiarizes middle and high school girls with STEM careers.
To determine the expression pattern of apl-1, transgenic worms were generated expressing an apl-1 gfp apl-1 gfptein driven by the endogenous apl-1 promoter.
Treatment with an APL-specific protocol was not associated with significantly fewer microbiologically documented sterile site infections when only intensive treatment courses were included (Table 3).
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