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In the event that an annotation exists for the genome of interest, reads matching annotated splice junctions can be filtered out of the input in order to focus the supersplat analysis only on the identification of potential novel introns.
The rows of the annotation matrix A represent f distinct biological functions, e.g., GO categories, and the elements a i, j hold indicator variables whose value depends on whether an annotation exists between the function i and genomic variable j.
Matrix of functional annotations: binary annotation matrix A whose rows represent f different biological functions, e.g. GO categories or KEGG pathways, and whose cells hold indicator variables whose value depends on whether an annotation exists between the function i and gene product j.
Similar(57)
A better functional annotation exists for genes implicated in heart disease [43] that in many instances are also expressed in slow skeletal muscles.
No annotation exists for any of these ORFans, which means that they are currently annotated as hypothetical proteins.
Currently, no known function or annotation exists for these three open reading frames.
Subtractive hybridization is also able to detect entirely novel transcripts for which no previous annotation exists [ 12, 13].
A visual representation for the annotation of the Concept Recognizer for the given data sentence is shown in Fig. 2, and similar annotation exists for the sentence that includes the clinical question.
Because little gene annotation exists for the bat genome, all distinct tags were aligned against the well annotated NCBI human and mouse Refseq cDNA sequences using SOAP2 [ 54, 55].
If the pathogenic mutation of this case has not yet been described in the literature and no 'pathogenic' annotation exists, the user can look for annotations that discuss patients with similar phenotypes or basic research scientists that talk about unpublished experimental data for this gene.
Never-smoking patient history was inferred if a specific annotation existed, and/or if pack-years were equal to zero (Beer et al. and GSE11969).
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