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The randomized crossover trial (Phase 1) is supported by an ancillary trial (Phase 2) of longitudinal-observational design to assess the longer term effectiveness of sodium restriction.
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In the ACCORD trial, for which referred participants were felt to be capable of adhering to a very complex protocol, 20% of those in the ancillary trial of cognition were found to have undiagnosed cognitive dysfunction at baseline (J. Williamson, personal communication) (60).
For example, as of August 2011, the ITN had 42 active primary trials and numerous ancillary trials taking place at 158 domestic and 10 international sites.
The present study has been organized as an ancillary to the main trial.
Accordingly, we compared markers of tubular and glomerular damage in an ancillary study of a randomized trial comparing sirolimus and cyclosporine.
This study served as an ancillary study to a parent trial that investigated the feasibility of an athlete modified cognitive dissonance-based program (AM-DBP) and an athlete modified healthy weight intervention program (AM-HWI).
This research was carried out as an ancillary study to the Macrolide trial of the NHLBI COPD Clinical Research Network CRNNHLBI COPD Clinical Research Network CRN
Further, in an ancillary study to the Polyp Prevention Trial (6), visceral fat area measured on CT was not associated with adenoma recurrence.
The Effect of Targeting Inflammation Using Salsalate on Flow-Mediated Dilation (TINSAL-FMD) was conducted as an ancillary study to the parent trial.
Similarly, Albu et al. (13) presented an ancillary investigation of the LookAHEAD trial in which they measured FFA during an euglycemic hyperinsulinemic clamp in 26 men and 32 women with obesity and type 2 diabetes participating in the intensive lifestyle intervention arm of LookAHEAD.
This was an ancillary study of a randomized clinical trial held in the Fall of 2008 at the University of Rhode Island.
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