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It is only with clear goals in mind that one can design a suitable data collection instrument and an analytical plan.
Each study adopted collaboration guidelines and established a consensus on phenotype harmonization, covariate selection and an analytical plan for within-study genetic association and prospective meta-analysis of results across studies.
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In an a priori analytical plan, the relationship between baseline ADMA and mortality among sepsis patients was examined using logistic regression, with ADMA divided into quartiles as previously described [29].
A central protocol for anonymous data cross-linkage and a central analytical plan was developed.
Problem formulation has been widely considered from the perspective of transgenic plant risk assessments [ 20, 29, 30, 34] as a means to identify the nature of questions that are germane to a given case of risk assessment and to arrive at a practicable analytical plan for risk characterization.
Analyses were done for intention to treat (ITT) and according to protocol (ATP) cohorts, following a predefined analytical plan.
The questions detailed in this grant are presented below followed by a prespecified analytical plan.
Survey data were checked for completeness on site, and hardcopies sent to Tanzania for double entry into a single database using DMSys and the analysis done centrally using a predefined analytical plan.
This approach leads to a focused analytical plan to address specific knowledge gaps, rather than merely conducting a wide array of studies, as suggested by Strandberg et al. [ 39].
A detailed analytical plan is available as Additional file 2. The AUDIT trial is generously funded by the Institution for Social and Policy Studies and the Leitner Program in International and Comparative Political Economy, both at Yale University, and by New York University's Department of Politics.
For comparison between studies, it would be helpful if studies used a clear analytical plan to test specific hypotheses and collect all necessary confounding variables for that purpose instead of performing data-driven analysis.
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