Exact(5)
Therefore, an alternative trial design to determine the lowest effective dose of a new compound that minimizes the number of unwanted pregnancies occurring during the trial is needed.
The covariates included in the final models can predict the efficacy of fingolimod versus placebo in an alternative trial population.
A comprehensive cohort study, where all patients fulfilling the eligibility criteria for a trial are followed up regardless of their consent to randomisation, may be an alternative trial design to overcome these obstacles.
This is followed by several approaches more explicitly accounting for intra-individual effects, albeit in quite different ways – latent growth and growth mixture models, and series of n-of-1 n-of-1 n-of-1trials latter being an example of how an alternative trial design can be combined with specific methodological approaches to model HTE.
Indirect comparisons using predicted RRs for fingolimod in an alternative trial population were significantly greater than 1 for all analyses versus DMF in a pooled DEFINE and CONFIRM population and for analyses versus teriflunomide 7 and 14 mg in a TEMSO population (with the exception of the clinical composite for the teriflunomide 14 mg comparison in which only a positive trend was observed).
Similar(55)
A variety of alternative trial designs (such as stepped wedge designs, pre-randomisation and cluster randomisation) are discussed.
Seeking to curb the sharp rise in litigation over environmental disputes, Congress has created the first Federally financed institute to encourage mediation as an alternative to trial.
At the same time, the Brooklyn district attorney's office has been offering the john school, a five-hour class called Project Respect, as an alternative to trial to people arrested for patronizing an adult prostitute, defined by New York State's age of consent law as 17 or older.
He said: "Zero tolerance will not overburden the courts because the police will make pre-charge community payback schemes an alternative to trial.
In this process, both parties retain separate attorneys whose job it is to help them settle the dispute through problem solving and mediation, as an alternative to trial.
Alternative trial designs can be considered.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com