Klee et al. conducted an alternative modification of the biosynthesis pathway with the removal of ACC by the addition of the enzyme ACC deaminase, found in bacteria, to Solanum lycopersicum which significantly delayed ripening of the fruit.
This class of drugs was never specifically tested in a defined KRAS mutant NSCLC population, in part due to the recognition that KRAS could be undergo an alternative modification which would allow it to localize to the membrane even in the absence of farnesylation.
The other one, an alternative modification technique that affects only the near surface layers of UHMWPE, is swift heavy ion (SHI) irradiation.
In this study, we present an alternative and simple modification to the TRIzol® and TRIzol®LS manufacturer's protocol, applicable to samples processed directly in TRIzol® for nucleic acid extraction.
Moreover, in an emerging alternative, modifications in the design of classic microcapsules have given rise to systems that deliver cells with regenerative purposes.
As an alternative approach to modification of either the steroid nucleus or the C2 position of 2-MeOE2, the C3/C17 hydroxy groups were sulphamoylated to give 2-methoxyoestradiol-3,17 2-methoxyoestradiol-3,17 2-methoxyoestradiol-3,17, 2) (Howarth et al, 1994; Purohit et al, 1995a, 1995b; Raobaikady et al, 2003; Newman et al, 2004; Leese et al, 2006).
Immobilized anti-BMP-2 may be used as an alternative surface modification strategy to enhance osseointegration.
GM-CSF as an alternative to dose modification of the combination zidovudine and interferon-alpha in the treatment of AIDS-associated Kaposi's sarcoma.
Intracellular delivery of proteins offers an alternative to genetic modification or siRNA transfection for functional studies of proteins in live cells, especially for studies in cancer cells for therapeutics development.
This shows that regions enriched with transcription factors can generally be used as an alternative to histone modifications and other markers (such as DNase hypersensitivity) to identify genomic regions involved in gene regulation.
However, the fact that the K99R mutant was less effective in rescuing its substrate indicated that the alternative modification of this lysine, namely ubiquitination, resulted in USP25m activation.
