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However, in the present study, it was taken into consideration as an alternative endpoint delivering additional information on ecotoxicity.
Treatment with DMARDs at 52 weeks was selected as an alternative endpoint.
ORR is currently being revisited as an alternative endpoint after the introduction of modified RECIST assessment in HCC.
A post hoc analysis of the AF Follow-up Investigatiof of Rhythm Management (AFFIRM) study also investigated CV hospitalization as an alternative endpoint for death.
In addition to analyzing association of biomarkers with pCR as an endpoint, the correlation of biomarkers with tumor size (degree of tumor shrinkage) was also measured as an alternative endpoint.
As exposure at higher concentrations of NPs interfered with resazurin reduction measurements, as observed by us and others, we measured intracellular ATP content as an alternative endpoint for cytotoxicity.
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The use of an earlier alternative endpoint would allow to shorten clinical trials and to evaluate treatment effect with better specificity.
Similarly, there is an alternative CNV endpoint 5 kb upstream of the common CNV endpoint.
In conclusion, the overall results of our study should help prioritise the endpoints to be statistically evaluated as surrogate for OS and highlight original potential alternative endpoint.
In any case, in research, alternative endpoints play a major role by increasing the knowledge on the mode of action of ENMs. 2.
As these agents may have more of a cytostatic than cytotoxic effect, alternative endpoints to objective response may be appropriate.
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