With three minutes to go, a mistake by Boyce allowed substitute Danny Welbeck to square for Van Persie, who gratefully clipped his second and United's fourth.
A well-worked move allowed substitute Kevin Gameiro to find Aleix Vidal down the right who cut the ball back for Iborra to finish.
Kris Boyd scored the first of the goals from a free-kick that seemed a generous award, while a dreadful error from defender Darren Barr allowed substitute Steven Naismith to double the lead in the closing minutes.
A rush of blood to Williams' head allowed substitute Forrest to round the goalkeeper and set up Teemu Pukki in front of goal, but the Finland striker hesitated as McGivern blocked the low effort.
Leeds' hopes of a comeback were undermined by their own farcical defending, however, as indecision between Silvestri and Giuseppe Bellusci allowed substitute Jones to slot into an empty net and ease Cardiff's nerves.
Any hopes of Chelsea snatching an equaliser were ended shortly after as Ivanovic's poor backpass allowed substitute Graham to run in, round the keeper and fire into the empty net.
McPake allowed substitute Magennis to turn inside the penalty box and the Northern Ireland international's low cross was poked in by Rae from four yards.
And more poor defending compounded Norwich's miserable night when Surman's careless pass allowed substitute Powell to run through and complete the scoring only four minutes after coming on.
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But a back header two minutes before half-time by Nigeria defender Ambrose came up short, allowing substitute Fernandao to pull a goal back for the visitors.
But with 10 minutes remaining Wales' encouraging performance was undone when Vaughan lost possession on the edge of his area, allowing substitute Trajkovski to drill home a low shot and hand Macedonia victory.
