Sentence examples for an agent of significant from inspiring English sources

It is not fair to reveal too many of the novel's events, which replace characterization as an agent of significant action.

Because of high mortality rate and its potential transmission by inhaled aerosols, pneumonic Y. pestis represents a significant concern as an agent of bioterrorism [3].

The goal of the article is to provide a clearer understanding of how melatonin and its related analogs interact with melatonin receptors with the hope of developing important tools and agents of significant clinical and scientific importance.

Nearly one and a half centuries have passed since Koch's discovery of the causative agent of tuberculosis; significant progress has been made with declining death rates globally but the disease nonetheless remains a leading killer in the developing world and a public health threat in the United States as well.

Inflamed vascular endothelium has been recognized as an attractive site for targeted delivery of therapeutic and imaging agents because of significant differences in the expression of surface receptor proteins between normal and inflamed endothelium.

Therefore testing of combinations of BPs with other agents is of significant interest in the treatment of various cancers.

Vancomycin was associated with the highest likelihood of major dose deviations, reflecting difficulties in adopting more recent and probably more controversial dosing recommendations of an agent known to have significant side effects [ 38].

Burkholderia pseudomallei is the causative agent of melioidosis, a disease of significant morbidity and mortality in both human and animals in endemic areas.

A recent review by Kevin Lafferty and coauthors examines the ongoing challenges associated with controlling the emergence and spread of disease within fisheries and aquaculture, highlighting a number of significant infectious agents with severe economic impacts.

In humans, it is a leading causative agent of gastroenteritis with significant impacts on childhood mortality in the developing world [ 4] and among HIV positive patients in Sub-Saharan Africa [ 4, 5].

It is an effective agent without significant risk of hypercalcaemia or worsening metabolic acidosis, and clinical studies in humans have demonstrated its tolerability for short- and long-term administration [ 21].