Alternatively, the patients with psoriasis as an adverse event may have a genetic predisposition to psoriasis, which after all is not uncommon (prevalence 2.5%), in addition to their arthritis.
Taken together, overall, it appears quite clear that β-adrenergic blocking agents can have an adverse effect on the outcome of an anaphylactic episode and perhaps can increase the predisposition toward these episodes.
It is well documented that Asians have an ethnic predisposition to adverse body fat distribution and metabolic syndrome (1); hence, optimal cutoff points for waist circumference have been established for South Asians (9); by using this cutoff, the prevalence of the metabolic syndrome in this population is estimated to be 10 30% (15).
With the ability to identify a genetic predisposition for adverse events following vaccination, immunization programs might decide to screen for this genetic risk factor.
But, if I find somebody that has a predisposition, a genetic predisposition, or a chromosomal predisposition toward substance abuse, it doesn't mean I should cave in to substance abuse.
The sensitivity to electromagnetic fields may result from an acquired lower resistance against adverse effects or a genetic predisposition [ 19].
Interestingly, the co-twins of the male probands differed remarkably from those of female probands in the same twin cohort, whose co-twins were mainly healthy [10], which supports the hypothesis presented by Strober et al. [5] suggesting that in order to develop an eating disorder, men require a stronger genetic predisposition and/or more adverse environmental factors than women.
Frailty is an important predisposition for falls and associated adverse health conditions [ 3].
Our population-based results support, but do not prove, the double-hit hypothesis that an insult such as maternal infection during critical periods of neural development sets up a predisposition toward severe adverse outcomes when exposed to asphyxia [ 19].
Conclusions: Patients after Kawasaki disease tend to have a more adverse cardiovascular risk profile potentially indicative of an increased predisposition to premature atherosclerotic changes.
Previous studies have demonstrated a clear association between RYR1 gene mutations and susceptibility to malignant hyperthermia, which is a pharmacogenetic predisposition to potentially deadly adverse reactions that occur in response to volatile anesthetics and muscle relaxants [ 13– 15].
