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NSAIDs have huge prescription volumes mostly based on the following two benefits, one is an increase of aged patients necessitating NSAIDs prescription to relieve degenerative change-induced pain and the other is an additional trial for either the prevention of colon polyps or the escape from ischemic cardiovascular diseases [ 1, 2].
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We included three additional trials for a further assessment of the effect of pyronaridine on liver function (Ringwald 1996; Ringwald 1998; Poravuth 2011).
More details are sure to come out: Lula faces four additional trials for charges including corruption, influence peddling, and obstruction of justice.
We searched the references of the identified studies to identify additional trials for inclusion.
Compared with the previous Cochrane review, 16 our analysis included 16 additional trials for the meta-analysis of the risk of insomnia events and 23 additional trials for the pooled analysis of abnormal dreams.
This resulted in 2 papers on epidemiology of pneumonia, 2 papers on the epidemiological effect of vaccination, and 5 trials on pneumococcal vaccination for CKD; 2 systematics reviews and 2 additional papers covering 14 trials for transplant recipients, and 1 systematic review and 5 additional trials for patients with nephrotic syndrome.
One should note, however, that the Food and Drug Administration recently rejected the use of pirfenidone for the treatment of IPF, citing the need for an additional clinical trial to prove efficacy given that the drug worked in one of the two trials and questioning whether the benefit provided by the drug was meaningful (InterMune press release).
References listed in each included trial were searched for additional trial reports.
Moreover researchers in the field were contacted and asked for additional trial reports.
Although previous meta-analyses have concluded that acetylcysteine is beneficial, the recent availability of additional trials calls for reassessment of current evidence.
One additional trial (topic: food) was used for practice purposes at the beginning of the experiment and was not included in the analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com