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In this review, we combined observational evidence of an additional randomized trial with a previously reported trial and prospective and retrospective cohort studies.
61 An additional randomized trial of rivaroxaban was performed separately in Japan, the J-ROCKET AF trial.
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Of course, additional randomized trials clarifying an optimal dose and focusing mainly on the high-risk group of patients are needed, and head-to-head trials directly comparing both of these agents are necessary.
Second, an additional randomized controlled trial showing efficacy of omalizumab in severe asthma-associated AD was published.
17 The main differences between the meta-analysis by Gui et al 17 and the present study are, first, that we included an additional randomized controlled trial 29 and, second, that the outcomes addressed in the two meta-analyses were not completely coincident.
Since publication of the two University of Leuven IIT trials [ 4, 5], several additional randomized trials conducted across a range of critically ill populations have failed to show a benefit in survival and an increased risk of hypoglycemia with IIT compared with conventional therapy.
Additional randomized trials recently have reported conflicting results.
Because, on average, chronic LBP patients have hypolordosis, additional randomized trials should be performed to evaluate the clinical significance of restoration of the lumbar lordosis in chronic LBP subjects.
Additional randomized trials of palivizumab have been published since the original meta-analysis.
Additional randomized trials involving omentectomy alone without bariatric surgery will be necessary to clarify the importance of the omental fat depot in obesity-related metabolic disorders.
An update of the SMAC analysis was published in 2008 and included patients from the 1997 meta-analysis and four additional randomized trials.
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