Sentence examples for an additional potent from inspiring English sources

BAY 94-9343 (anetuman ravtansine) is a fully human antimesothelin antibody coupled via a reducible disulfide linker to DM4, a microtubule-targeting toxophore that shows highly selective cytotoxicity against cells with high levels of mesothelin expression with an additional potent bystander effect.

These features provided a road map for designing additional potent chemical derivatives and fragments of the original lead compounds to perturb the AKAP-Lbc and RhoA interactions.

Target identification is not essential for drug development, but nevertheless improves medicinal chemistry efforts and allows for the design of target-based high-throughput assays that may yield additional potent inhibitors of a target of interest.

"Our results provide an additional highly potent, well-tolerated treatment option and highlight the simplicity of treatment resulting from combining several antiretrovirals in a single pill.

A structure activity relationship study of this compound further identified the 4-chloro (IC50 = 0.18 μM) and 3-chloro (IC50 = 0.17 μM) analogues as additional potent CtBP inhibitors.

This burgeoning relationship brought additional potent allies.

Therefore, additional potent therapeutic strategies are urgently needed.

Two additional potent isoquinoline RAF kinase inhibitors, NVP-AAL881-NX and NVP-LBT613-AG-8 NVP-LBT613-AG-8 NVP-LBT613-AG-8 NVP-LBT613-AG-8d iNovartisand in vivo against a panel of poorly differentiated thyroid Cambridgell lines (Ouyang et al, 2006).

The efficacy of cancer-selected killing by the 86S, better than 84AS, advocates that continuous screening for extensive regions of antisense nc-rRNAs with oligonucleotides may identify additional potent anticancer targets.

Recently, pro-inflammatory chemokines have been implicated as effective angiogenic promoters in several cancers, including ESCC., Besides directly mediating angiogenesis in endothelial cells, chemokines may also enhance the infiltration of macrophages/monocytes and neutrophils as additional potent manufacturers of angiogenic cytokines and chemokines.

As an additional example, the potent angiogenic factor VEGF is markedly over-expressed in various cell types in the skin of SSc patients [ 55, 56].