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We thereby bring an additional level of complexity in the highly complex role played by PGE2 in colon cancer progression.
The state regulation does not simplify the problem but instead imports an additional level of complexity.
Crusoe microprocessors, which are made by Transmeta, have an additional level of complexity: special software that translates all commands.
Biological systems have an additional level of complexity compared to other chemical systems because of the effects of metabolic regulation, a defining feature of biosystems.
The sensitivity of inverse agonists and protean agonists to receptor desensitization implies an additional level of complexity in structure activity relationships.
From a physiological point of view, this modulation can be seen as an additional level of complexity in the cell signaling process.
We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers.
Intact plants have an additional level of complexity since they are living systems which critically depend on transport and signalling processes between and within tissues and organs.
The complexity of the cancer biology being the result of so many different interactive mechanisms whether driving or not the process of cancer cells is an additional level of complexity to approach more inclusive clinical trial access.
This commentary highlights an additional level of complexity in the autophagy landscape, specifically that autophagy can switch its function even within the context of a specific external stress and/or a biological cancer model.
Recent advances have demonstrated that placing genes in a specific nuclear context plays an important role in the regulation of coordinated gene expression, thus adding an additional level of complexity to the mechanisms of gene regulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com