It is therefore possible that a given gene needs duplicates as it is essential in such a way that an additional copy is required to ensure a low lethality if loss-of-function occurs in this gene [32].
Reminders and an additional copy were sent two weeks later for unreturned surveys.
The subjects paid to have their pictures taken, and they (or their estates) are the ones who should be contacted before any additional copies are made, exhibited or sold.
Three of these copies localized to the respective region at chromosomes 16 while the occasionally occurring additional copy was part of a marker chromosome containing only a small amount of material from chromosome 16 (Fig. 3A).
Think software: Once Microsoft shelled out to develop the code for its Windows operating system, the incremental cost of printing each additional copy was next to nothing.
This additional copy is probably expressed at a lower level than the original transcript which would explain the imbalance in the RNA-seq data.
More precisely, the marginal cost of digital products, or the cost of delivering one additional copy, is approaching zero.
Next, a four component Gaussian mixture model (one component for each of the following copy number states: deletion, copy-neutral, 1 and 2 additional copies) was fitted to the smoothed copy number ratios with a constraint on the differences between the mixture means.
Additional copies are available for a charge of $10 per transcript.
If a cluster contains more copies of a label than the multiset ℳ, these additional copies are removed from the cluster, independently of all other clusters.
