Of course, there were many additional compounds that also exhibited a positive correlation with the RAS activation phenotype, although their utility will require further experiments.
Another study identified four additional compounds that did not elicit a retinue on their own, but synergized with QMP to produce a stronger retinue response [17].
Metabolon also has the ability to measure additional compounds that do not currently have a chemical standard, but this was not done in this study.
Here, we asked whether it would be possible to identify additional compounds that increase C. elegans longevity by conducting a large-scale screen of compounds with known pharmacological targets in mammals.
This pharmacophore has been exploited to identify additional compounds that demonstrate significant inhibitory activity against Pfmrk.
Although several drugs are in development, no approved therapies for TTR amyloid cardiomyopathy are yet available, so the identification of additional compounds that prevent amyloid-mediated cardiotoxicity is needed.
These data demonstrate that interactions with the GluK1 subunit are preserved in analogs with substitutions at C10 in NDH and further reveal the determinants of selectivity and pharmacological activity of molecules acting on kainate receptor subunits, which could aid in design of additional compounds that target these receptors.
This could be useful for selecting and classifying additional compounds that may also require DEA Schedule I status classification [13, 14].
For two of the patents IBM SIIP found 32 additional compounds that are not in SureChEMBL, whereas SureChEMBL did not find any compound that is not also in IBM SIIP.
Ultimately, we should be able to identify additional compounds that could be immediately useful to treat patients with the disease while we await the approval of a vaccine.
