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In deeply sedated and paralyzed patients, receiving analgesic support based on a scale score an additional administration of short-acting analgesic drug, such as Remifentanil, seems not to be necessary for acute pain control.
A greater number of patients in group A (43.5%, 20/46) received an additional administration of analgesic than that in group P (36.2%, 17/47), although the difference was not statistically significant.
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We therefore repeated the F MRS analysis at a later time point without any additional administration of TAPET-CD.
When the prescription was sent by post or fax, the patient also had to pay an additional administration fee of about 7 Euro (54 NOK).
Thus, while the use of an additional administration route would be of interest, it would be a conceptual replication.
We agree adding an additional administration route would be of interest to test if the effect is dependent on the route of antibody delivery, however, as the reviewers have already described, Willingham and colleagues did not use this approach.
Ovariectomized rats were given a single dose of either 0.25 mg or 1.25 mg of CC prior to a hormone-priming regime of progesterone (P4) for 3 days with a single additional administration of oestradiol 17β (E2) on day 3. Animals were killed 24 h after final treatment.
Our study shows that in deeply sedated patients receiving analgesic support based on a scale score, additional administration of short-acting analgesic drug, such as Remifentanil, does not seems to be necessary for acute pain control assessed by BIS variation.
The effects on pulmonary gas exchange and oxygenation measured at 35 minuts after sedation is most likely an effect of the additional administration of butorphanol.
Additional administration of an aromatase inhibitor should be considered if breast cancer is present [ 7].
Though impractical relative to minimizing patient fatigue during questionnaire administration, the additional administration of a social desirability questionnaire along with the PAID and other questionnaires would have been helpful in determining whether this was indeed true for this study [ 16].
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