Sentence examples for an adaptive trial from inspiring English sources

Matching multiple heterogeneous clinical profiles with a number of potentially effective treatments requires an adaptive trial design that can adjust for these complexities.

The key idea underlying the concept of an adaptive trial design is that instead of fixing the parameters of a trial before its onset, greater efficiency can be achieved by adjusting them as the trial progresses [8].

To solve such problems effectively, in this paper, we propose a new constrained optimization evolutionary algorithm (COEA) named CACDE that combines an adaptive trial vector generation strategy-based differential evolution (DE) algorithm with a cluster-replacement-based feasibility rule.

We used an adaptive trial design with two cohorts.

As data accumulate in an adaptive trial, the allocation ratio is changed to favor the treatment group that appears superior.

Furthermore, regulatory bodies typically require that a model is specified in advance when utilizing an adaptive trial design.

The same relative performances of different sample selection methods we observed in the first set of experiments were maintained when the experiment was extended to a simulation of an entire adaptive trial.

Given the new availability of citrate regional anticoagulation, we have designed a confirmatory, adaptive trial whose first step will be to prove this new technique easily allows high volume of plasma treated with CPFA.

The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) trial is an adaptive platform trial testing multiple drugs to slow or prevent the progression of Alzheimer's disease in autosomal dominant Alzheimer's disease (ADAD) families.

In an adaptive clinical trial (ACT), key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself.

Compared with a traditional, fixed trial methodology, a well-designed adaptive trial can increase the probability of correctly identifying a truly effective therapy and can hasten the identification of futility, allowing scarce resources to be more rapidly directed towards the next promising target or project [ 111].