To measure the discriminative ability of an active cluster, we adopt the idea of SVM-RFE method in [ 2].
Here d ¯ (A i, Δ') is the 'average' Euclidean distance of centroids between an active cluster in A i and its closest cluster in Δ' = { C1, C2}.
As defined by [7], an active cluster as a non-singleton cluster for which the percentage of active molecules in the cluster is greater than the percentage of active molecules in the dataset as a whole.
In addition, according to [13], an active cluster can be defined as a non-singleton cluster for which the percentage of active molecules in the cluster is greater than the percentage of active molecules in the dataset as a whole.
The results are applied to a specific application where active clustering of like services is used to aid load balancing in a highly distributed network.
Not surprisingly, it is becoming increasingly clear that dysregulation of Pol I transcription is linked to the aetiology of a broad range of human diseases [ 20]. rDNA transcription underpins the structure of the nucleoli, which form around active clusters of rDNA [ 21].
Horizontal black bars underneath cluster indicate part of active cluster, a subset of which were used to generate pharmacophores using the Ligand Scout program (shown underneath each Or in two orientations).
For instance, the PPAR signaling pathway is enriched in active cluster 2 of obesity, which has a vital function in adipocyte proliferation and differentiation in liver, muscle and adipose tissues [ 9].
However, when a failure of the active cluster is detected, the DNS record is switched to the next available cluster in the failover stack.
Moreover, in the case of the 74 kb sequence, assembled using data concerning the nine endoxylanase-positive clones, a putative xylan-active cluster, composed of six different ORFs encoding putative members of families GH10, 11, 43, 115 and CE1, was identified.
