Exact(1)
Our findings have important implications for PPI druggability assessment by fragment screening as they reveal an accessible threshold for fragment detection and validation.
Similar(59)
In order to define the accessibility of the amino acids to some putative external ligand - with a future drug in mind, using the 3D protease structure PDB ID: 1HSG[ 25], we computed the surface accessible to the solvent, using the ASA software [ 51] available at RPBS [ 52], and considered "accessible" all amino acids with an accessibility threshold greater than 25%.
All AAs having an accessibility threshold greater than 25% are considered "accessible".
HA: highly accessible, A: Accessible, MA: moderately accessible.
The prevalence and burden of phobic disorders call for effective and cost-effective treatment options and the Internet offers an accessible and widespread platform to disseminate low-threshold treatment for phobias.
Even in the best cases, with optimal specimen preparation, an accessible antigen and a highly specific, high affinity antibody there is still a threshold of antigen below which it cannot be detected (Griffiths et al. 1993; Fritschy 2008).
She writes in an accessible, melodic style.
The bigness guarantees attention, an accessible spectacle.
"Exercise is an accessible, low-cost intervention.
1. Find an accessible venue.
"It's quite an accessible look.
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