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Alternative approaches would be to use an accepted threshold or trigger for defining effects or recovery.
In our study, a >4-fold titer rise in antibody was used as serologic evidence for influenza infection, which is an accepted threshold in the field (31 ).
However, given the current lack of an accepted threshold level for adverse health effects, any nonzero PM standard represents the air-pollution related heair-pollution relatedcy makers consider "acceptable" (Peters et al. 2004).
The mTSS value of 0.5 was chosen because it is an accepted threshold that has been previously used to assess radiographic progression in ADEPT [ 14] and early RA [ 20].
23 While a 10-point change in an individual patient's EORTC QLQ-C30 item or domain is an accepted threshold for clinically meaningful improvement, 24 different thresholds have been proposed for intergroup changes for individual QLQ-C30 QOL scales.
There is a relationship between recurrent dislocations and failure of arthroscopic Bankart repair with increasing size of the Hill-Sachs lesion, although an accepted threshold value for Hill-Sachs bone loss has not yet been determined [ 9, 27, 28].
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Hence, the 5α-reductase 1 model was safely constructed based on the crystal structure of 5β-reductase 1 (PDB: 3CAS 38) thanks to a 40% sequence homology, in view of a commonly accepted threshold of 25%to30%0% of the minimal homology required for a length of 80 to 100 residues (typical domain length).
The coach-led group achieved a mean percentage weight loss exceeding 5%, a commonly accepted threshold of clinically significant weight loss, and the upper 95% confidence limit was at least 3% weight loss, across the baseline BMI categories.
While model overfitting cannot be completely ruled out here, it is likely that such a strict bifurcation of samples in heat maps via two-way clustering of both gene classifiers and samples is simply a more stringent criterion than FDR 0.25, a commonly accepted threshold for GSEA.
In this study, we focussed on mosaic events of at least 2 Mb in size, a generally accepted threshold for large structural alterations (10), allowing a fair basis of comparison for the different chip designs we analysed, and concordant with a recent study that used an SNP chip design and algorithmic protocol similar to our own (11).
We chose this range because (1) <70 mg/dl is a widely used definition of hypoglycemia and (2) ≥140 mg/dl is <span class="lh lhl">a widely accepted threshold for hyperglycemia.
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