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This study investigates a methodology to analyze the ideal pile size to reach an acceptable variability given the in situ quality fluctuations.
In conclusion, the 7-day assessment should provide reliable information from the bioassay on differences between EPNs at an acceptable variability.
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The hard capsule is a suitable excipient for QbD drug development and manufacturing with acceptable variability within a consistent and narrow range, well defined by its specifications.
Conclusion: The authors have determined a pharmacokinetic model for sufentanil that can be used to maintain desired target concentrations of sufentanil before cardiopulmonary bypass, with a high degree of accuracy and acceptable variability.
Robust design maps are derived from the analysis which provide for selection of cell temperature and anode and cathode pressures as functions of the input parameter uncertainty and target maximum acceptable variability in the power density.
The limits of acceptable variability were set at 15% for all the concentrations, except at LLOQ, for which 20% was accepted.
While the level of acceptable variability of image analysis data has not been established, the small SDs for PA14ΔbifA indicates high consistency in biofilm formation on the un-patterned controls.
In this study, the relative standard deviation determined for each target analyte was found to be less than 10%%, Table 2, which indicates the acceptable variability of the analytical results (Eurachem/CITAC 2003; EC 2010).
In this study, we only included experiments in which this change did not exceed 20%, which we consider as acceptable variability for extracellular in vivo recordings.
All ad hoc questions were pilot tested and showed acceptable variability and response rates.
Concerning repeatability, 20 compounds showed acceptable variability below 20%% RSD, most of which (14 OPAHs), had RSDs below 15%% (Table 1).
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