There are further studies suggesting that people with delusions are worse than controls at inhibiting the evidence of their senses when it conflicts with other things they know (Langdon et al. 2008b) and that they have an accentuated need for closure which comprises a desire for clarity and structure (see Kruglanski 1989, p. 14).
The transition from an intra- to extra-uterine environment leaves its mark in deciduous teeth and first permanent molars (the mesial cusp) as an accentuated enamel incremental ring called the neonatal line (NL) [19], [20] (see Figure 2).
A FRET based G protein sensor suggested that in contrast to translocating Gβγ, non-translocating Gβγ subunits do not dissociate from the αq subunit on receptor activation leading to prolonged retention of the heterotrimer state and an accentuated response.
This was immediately followed by plasma membrane blebbing cellular fragmentation and plasma membrane rupture, accompanied by an accentuated drop in green fluorescence.
Experiments in healthy subjects exposed to normobaric hypoxia showed an accentuated heart rate and activation of muscle sympathetic nerve activity in response to rhythmic handgrip exercise [ 31, 32].
Upon examination at age 19 years, the patient presented with short stature (140 cm), muscular build, scoliosis, and an accentuated lumbar lordosis.
The double-mutant mice presented with an accentuated cardiac pathology and died of congestive heart failure in the first 2 months of life.
Using the Sharp Score for joint space narrowing, the Z-Score of the MCP articulations confirmed an accentuated reduction from score 2 (-0.39 ± 0.57 SDs) to score 3 (-1.83 ± 1.28 SDs) [ 9].
Moreover, 5-HT2C knock-out mice show deficits in habituation and an accentuated response to repeated stress exposure (Chou-Green et al., 2003), suggesting a role for the receptor in stress adaptation.
Thus, our working model proposes that NICD activity leads to both increased ciliary length and ciliary localisation of Smo, by two independent mechanisms, which together prime the cell for an accentuated response to the Shh ligand.
These mechanisms include a role for the human –1607GG polymorphism as a susceptibility factor for an accentuated response, which critically depends on the ability of β-arrestin1/2 to generate scaffolding and nuclear trafficking of phosphorylated ERK1/2.
