We also found that the combined effects of CC-3052 and INH resulted in a reduction in lung inflammation and accelerated resolution of lung pathology, as compared with mice treated with INH alone.
In contrast, wild-type mice treated with R-848, a specific TLR7 agonist in mice, exhibited accelerated resolution of allergic airway inflammation.
As MaR1 potently accelerated resolution of sterile inflammation and is present in human milk, we assessed its ability to enhance resolution of infection (Supplementary Figure 3c, d).
Of these newly identified SPMs herein, RvD2 and MaR1 each accelerated resolution of acute inflammation and infection (Figure 4, Table 2, and Supplementary Figure 2).
RvD2 and MaR1 were identified in human milk, and each individually accelerated resolution of inflammation, shortening the Ri from 26 to 12 h.
RvD2 and MaR1 (50 ng per mouse) administered 12 h after zymosan challenge (1 mg per mouse) each accelerated resolution, reducing neutrophil numbers and shortening the Ri by 33% and 40%, respectively (Supplementary Figure 2a, b).
Cfh deletion protected the mice from the pathogenic subretinal accumulation of mononuclear phagocytes (MP) that characterize AMD and showed accelerated resolution of inflammation.
Pharmacological activation of CD47 accelerated resolution of both subretinal and peritoneal inflammation, with implications for the treatment of chronic inflammatory disease.
These observations indicated that SkQ1 accelerated resolution of inflammatory phase.
Indeed, the addition of clarithromycin to patients with ventilator-associated pneumonia accelerated resolution of pneumonia and weaning from mechanical ventilation [ 14].
In mechanistic studies, tight glycaemic control with insulin reduced septicaemia and the need for prolonged antibiotic therapy, 9 prevented nosocomial infection, 10 accelerated resolution of inflammation 11 and reduced muscle catabolism.
