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The mcl1-101 mutation causes reduced CENP-ACnp1 in the central domain and an aberrant increase in histone acetylation in both domains.
Of 15 patients with recurrent gastric cancer, 14 (93.3%) showed an aberrant increase.
Of 104 patients with primary gastric cancer, 35 (33.7%) showed an aberrant increase in the circulating level of HGF.
In other tissues, cancer was associated with an aberrant increase in ELF5 expression, as seen in the cervix, colon, rectum, and uterus.
This p53-dependent apoptosis is, at least in part, due to an aberrant increase of c-Myc dosage (Onoyama et al., 2007; Matsuoka et al., 2008).
A reduction of FKBP12.6 protein impairs the binding and increases the open state of the RyR2 during diastole, thereby leading to an aberrant increase in diastolic Ca2+ leak [ 16].
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In the present study, it is worthy of note that focal MCMV infection of the fetal cerebrum globally induced a dramatic and aberrant increase in brain macrophages, including microglia, and this increase was dependent on the recruitment of precursor cells from other sites rather than in situ proliferation.
In contrast, concomitant nucleolar and nuclear distribution observed in aggressive tumours such as SCLC and BC is suggestive of a strong and aberrant increase of telomerase activation in fast-growing tumours that have acquired a large enough number of genetic lesions to escape senescence and apoptosis.
Importantly, chemogenetic activation of the LDTg to VTA pathway paired with a mild social stress promotes the development of depressive-like symptoms and the aberrant increase in VTA DA neurons activity.
Several studies have demonstrated the aberrant increase in HNRNPK expression in cancers.
It has been reported that aberrant increase of Ezrin phosphorylation at the T567 site generates increased cell survival and metastatic capabilities of cancer cells [ 18- 21].
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