15 The severity of encephalopathy at random allocation was assessed by amplitude of integrated electroencephalogram and by clinical assessment in the CoolCap study, by clinical assessment only in the NICHD study, and by amplitude of integrated electroencephalogram only in the TOBY trial.
The different levels are: (a) simple screening criterion, (b) the thermal spectrum replaced by a sinusoidal load (SIN-method) with constant amplitude and frequency and assessment of crack initiation and crack propagation in relation to a critical frequency, and (c) spectrum loading applied to crack initiation and propagation.
A trend for higher test retest reliability is observed for the topographic assessment of amplitude measures in healthy controls.
However, the potential clinical benefit of an improved assessment of amplitude and configuration regarding future functional impairment remains to be determined in longitudinal studies.
Use of multifocal VEP, which captures a significantly larger area of the visual field than pattern VEP and can provide topographic assessment of amplitude and latency, may provide a useful adjunct or alternative in the setting of acute optic neuritis (Klistorner et al., 2008, 2009).
On the other hand, the use of ROM (and hence RIROM and other related indices) can have some disadvantages: (1) it only compares the differences between the maximum and the minimum of the curves, independently from the data distribution; (2) the mean ROM of n curves can be very different from the ROM of the relevant mean curve, and it can affect the assessment of amplitude similarity.
However, a number of factors may complicate this assessment of amplitudes, and these will be addressed in the Discussion section.
At the 2-year follow-up assessment, SNAP amplitudes of the MDC and DS nerves in the IGT group were significantly smaller compared with those assessed 2 years earlier (Supplementary Table 2).
A controlled comparison of brachial artery flow mediated dilation (FMD) and digital pulse amplitude tonometry (PAT) in the assessment of endothelial function in systemic lupus erythematosus.
