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Additionally, an ancient sub-clade of NB-LRR proteins can 'help' amplify the function of NB-LRR proteins that sense pathogens [ 49].
Both IL-17 and IL-32 cytokines can reciprocally influence each other's production and amplify the function of osteoclastogenesis in the in RA synovium.
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Their roles could be promoting oncogenesis, or function as BRCA1+ modifiers to amplify the oncogenic function of BRCA1+.
In addition, bortezomib can amplify the proapoptotic function of cyclin D1, raising the possibility that cyclin D1 levels may be a marker for predicting the response to this novel drug.
The implications for miRNA gene amplification are still unknown, but miRNA genes with multiple copies may augment or amplify the physiological functions of individual miRNA genes.
The rapid response by NKT cells following activation can amplify and regulate the function of dendritic cells, Tregs, NK and B cells, as well as conventional T cells.
We proposed, therefore, that the effects of immersion and NPB might individually alter heart function and amplify the risks of developing IPE.
30 Thus, histones may also function to amplify the effect of circulating DNA through TLR9 activation.
Our results further suggest that effective therapeutic manipulation of these receptors will require defining the roles of specific lysophospholipid receptor subtypes, which may have opposing functions, and defining the impact of additional receptor pathways that may amplify or blunt the functions of LPA and S1P.
Although START domains are amplified in HD-Zip transcription factors, the function of the plant domains in lipid/sterol binding has not been verified, nor has the crystal structure been solved for any plant-derived START-subfamily domain to date.
Diminished thermostability can significantly amplify the biological consequences of compromised catalytic function.
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