Forest dieback and thawing of permafrost threaten to amplify global warming as stored carbon and methane are released into the atmosphere, giving rise to a self-amplifying feedback loop".
This concept is supported by our observation that circulating monocytes in SSc patients are phenotypically altered and amplify a positive feedback loop, mediated by versican and CCL2, between monocytes and fibroblasts.
A possible mechanism is that a weak asymmetry in activity or protein distribution across the cell is amplified by a feedback loop to produce an observable protein asymmetry, in a manner similar to that suggested for the generation of core protein asymmetry [ 26, 27].
Therefore, Bid may amplify an LMP positive feedback loop (Figure 6A) and is a potential mediator of LT-induced pyroptosis.
This extrusive signaling is amplified by a positive feedback loop between Slit-Robo2-Ena and JNK.
This perturbation could be achieved by coupling the system to a resonant cavity to create a new polaritonic potential surface, or to a material that responds mechanically or chemically to the reaction, such that a feedback loop amplifies the catalysis.
Production of methyl jasmonate is induced by systemins and also upregulates systemin precursor genes creating a feedback loop, amplifying the defensive signal.
The radiation of animals was likely due to the high atmospheric oxygen levels [26], which was produced as a "side effect" of the algal-climatic feedback loop (amplified by the fact that cold water can contain more dissolved oxygen than warm water [21]).
Therefore, JA is locally synthesized in response to light stress, and is also amplified by a positive feedback loop [ 24].
The TRF2-ATM-p53 feedback loop amplifies telomere-initiated, p53-mediated DNA damage responses leading to the rapid induction of cellular senescence or apoptosis, which may prevent DNA damage-carrying cells from contributing to tumor formation.
Given such a regulatory circuit, should Myod1 and Myf5 not undergo occlusion in non-muscle cells, any low-level expression of these genes caused by cellular noise is likely to get amplified through a positive feedback loop, which in turn could trigger the erroneous manifestation of muscle phenotype in non-muscle cells.
