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To reduce the amplifier sensitivity a feedback loop can be added to the architecture configuration A1.
A simpler but effective feedback correction technique to reduce the amplifier sensitivity to parameter changes is derived from [21]: the sign of the output current provided to the load is used as 1-bit control to check periodically which output transistor is on and to change consequently the inserted time-guard value.
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Parameters of the recording system were as follows: amplifiers sensitivity: 20 μV/div, filters: 1 100 Hz.
Parameters of the recording system were as follows: amplifiers sensitivity: 10 20 50 µV/div, filters: 0.3 500 Hz (for OPs extraction: 75 500 Hz), notch filters: off, time base: 5 ms/div, and artifact reject threshold: 0 µV.
Parameters of the recording system were as follows: amplifiers sensitivity −20 µV/div, filters: 1 100 Hz, artifact reject threshold –95%% (for the amplifiers range ±100 µV), notch filters were off, averaging: 200 sweeps, sweep time: 250 ms (time base: 25 ms/div).
Note that the individual silicon crystals present due to the second deposition do not appear conductive because the current pre-amplifier setting (sensitivity = 1 nA/V) was adjusted to the magnitude of the current in the pit.
Time-of-flight reconstruction (TOF) allows for faster convergence and reduced noise propagation; it is less sensitive to imprecise attenuation and scatter correction, and it works as a virtual sensitivity amplifier [32, 33].
On the basis of our results, we propose that T91/T93/T95 multiphosphorylation of c-Jun functions as a sensitivity amplifier of the JNK cascade, setting the threshold for c-Jun pro-apoptotic activity in neuronal cells.
Gold nanoparticles functionalized with DNA3 (DNA3-GNPs) were used as signal amplifier to enhance the sensitivity of the aptasensor.
The amplifier shows a linear sensitivity of 118 mV/fC and an equivalent noise charge of about 711 e−, for a detector capacitance of 5 pF.
Additionally, for the MCF amplifiers, an approach is presented to decrease the sensitivity of the amplifier performance to the variation of Gaussian beam waist utilizing the coupling between the Gaussian beam and the FM of the PCF.
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