The phrase "amplified area" is correct and usable in written English.
It can be used in contexts related to sound, signal processing, or any field where an area is enhanced or increased in some way.
Example: "The amplified area of the concert hall allows for better sound distribution, ensuring that every audience member can enjoy the performance."
Alternatives: "enhanced region" or "expanded zone".
An example of the former is region #79, which is paralog to the region 55715461 55763010 on chromosome 7 [35],that lies within the EGFR amplified area, The Pearson's correlation between the copy number values of the two paralog regions is 0.79.
The minimal common alteration within this amplified area in the SCLC cell lines contains only one gene, MAD1L1 (validated by Coe et al, 2006).
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA), encoding the catalytic subunit of PI3K, is located on the 3q26 amplified area and is found with high-frequency copy number (CN) gains and novel mutations in SCC [ 22– 25].
It showed the typical pattern of a high level amplification for the clones RP11-8C15 and RP11-89P22, whereas the apparently not involved clone RP11-9F13 was confirmed to be localized outside of the amplified area.
Representative analyses showing the distribution of methylation in the amplified area of the CpG island are shown in Figure 3. Consistent with breast carcinoma cell lines, methylation at individual CG dinucleotides was variable.
We observe that the KC-SMART selection of amplified areas ignores important genomic areas that we classified as "exclusively amplified" such as those harboring MET gene.
The amplified areas were a DNA fragment containing part of the 5′ end of each ECF sigma factor gene and the upstream region of the ATG initiation codon, and a DNA fragment containing the 3′ end of each sigma factor gene and the downstream region of its stop codon.
The exclusively amplified genomic area 2q23.1-2q35 harbors IDH1 gene (Isocitrate Dehydrogenase 1).
This study shows that with CGH it was possible to define an amplified chromosomal area, in which after a database search ABCA2 could be identified as a candidate gene involved in mitoxantrone resistance.
Complemented strains were checked by Southern blot analysis and an additional PstI control digest of the PCR-amplified areA upstream flank.
Other amplified chromosomal areas detected in breast cancer are 13q31, 17q22-24, 1q41-44 and 20q13.
