The trial details documented here are consistent with AMPLE trial protocol V.4 (date: 05/05/2014).
AMPLE trial design and patient eligibility criteria have been previously described.
A recent head-to-head clinical trial (AMPLE trial) demonstrated that subcutaneous abatacept was not inferior to adalimumab [ 16].
The AMPLE trial is a multicentred, prospective, randomised trial designed to compare IPC with talc pleurodesis for the management of malignant pleural effusion.
The Australasian Malignant Pleural Effusion (AMPLE) trial is a multicentred, randomised trial designed to compare IPC with talc pleurodesis for the management of malignant pleural effusion.
The head-to-head comparison between 2 different biological agents is available only in 2 RCTs, the ADACTA trial (comparing TCZ and ADA monotherapies) and the AMPLE trial (comparing ABT and ADA, both on top of MTX) (Table 2).
The AMPLE trial provided a noninferiority comparison of subcutaneous ABT and ADA, both administrated in combination with MTX, in a study population of 646 RA patients through a 2-year follow-up period [ 128, 129].
24 As a pragmatic real-life study, the AMPLE trial allows each centre to perform the talc pleurodesis as per their usual practice, including the choice of the size of chest drain used, timing of talc instillation and chest drain removal.
The ample numbers of trials that were completed and the fast running speeds indicate that rats with hippocampal lesions did not lack motivation or locomotor drive.
The Carnegie Mellon School of Architecture reported 20%-26 20%-26r test scores in classrooms with ample natural light and trials (pdf) have found that plants in classrooms can lead to improvements in spelling, maths and science of between 10% and 14%.
Dr. Robert M. Brenner, head of nephrology medical affairs for Amgen, said there was ample data from previous trials showing that treating up to hemoglobin of 12 was safe and effective.
