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The induction and importance of HO-1 in tumors were verified in murine tumor models in 1990s [ 16], and by now ample studies reported the upregulated expression HO-1 in many cancer cells [ 11, 16- 22], and suggested the involvement and importance of HO-1 in the formation, progression, metastasis and prognosis of cancers [ 36- 38].
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Ample studies have reported mutations in p53 in oesophageal carcinomas, with mutation frequencies varying from 40 to 90% (Jankowski et al, 1999; Mandard et al, 2000; Wijnhoven et al, 2001; Jenkins et al, 2002).
Notably, two studies reported seed bank changes in response to Phragmites management and recorded ample seedbank for passive revegetation.
Three studies reported this.
Earlier studies reported that Phragmites was not present in the seed bank (Van der Valk and Davis 1979; Wilson et al. 1993; Baldwin and DeRico 1999); however, more recent studies have found ample Phragmites seed in the seed bank (Smith and Kadlec 1983; Welling et al. 1988 a, b ; Leck 2003; Baldwin et al. 2010).
On one hand, free radical accumulation is an essential factor contributing to cell damage and mutation; meanwhile, intracellular ROS accumulation is responsible for mitochondrial membrane permeability which is reported by ample studies [ 29, 36].
There are ample studies to show how often they have been tried and how often they have ended in tears.
There are ample studies to demonstrate that immigrants are less likely to commit crimes.
There have been ample studies on the association between FcγRIIa and SLE [ 24, 28- 30].
Ample studies suggest that mitochondrial function is responsible for cell death and is considered a target for anticancer drugs [ 31– 31].
Despite ample biologic plausibility, this hypothesis is difficult to evaluate directly [ 5], and previous epidemiologic studies have reported conflicting results [ 6, 7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com