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There are ample experimental data in support of a causal link between tobacco smoking and HCC development.
Ample experimental data support the fact that tumour growth requires access to blood vessels and subsequent expansion of host vessels to provide nutrients for the growing tumour mass (Folkman, 1995a).
SAGE and related sequencing-based techniques are very effective for studying gene expression in organisms where well-characterized genome sequences are available, and they have been applied to a number of eukaryotic species [ 17, 19, 32] and the merits and success have been discussed very recently by Marco Marra and his colleagues with ample experimental data [ 12], albeit pitfalls do exist [ 13].
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These hypotheses were considered using the S. cerevisiae genome which has been re-annotated [ 13, 23] and is essentially definite with regards to protein size annotation and for which there is ample genome-wide, experimental data on available.
To develop the approach, we chose the well-described LacI-family of transcriptional regulators (PFAM PF00356), limiting the analysis to Firmicutes and focusing specifically on the model organism Lactobacillus plantarum WCFS1, which has a high number of LacI-family TFs for which we have ample experimental and transcriptome data for validation.
Seldom is there ample observational data to conduct a detailed model intercomparison using consistent data (e.g., the same emissions and meteorology).
Ample experimental and structural information was used to evaluate and support the predictions and inferences.
Figure 5A shows that there is ample agreement between the simulated and experimental data sets for the Seq control sample but the model slightly overestimates the amount of error introduced via Illumina miscalls.
As experimental data began to accumulate, Prusiner grew puzzled.
Unfortunately, and surprisingly, experimental data doesn't quite bear that opinion out.
"I preserve copies of experimental data which supports the original claims of these publications," she wrote.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com